BET, SRC, AND BCL2 FAMILY INHIBITORS ARE SYNERGISTIC DRUG COMBINATIONS WITH PARP INHIBITORS IN OVARIAN CANCER

BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer

Background: Homologous recombination Fabric Ottoman deficiencies (HRD) are present in approximately half of epithelial ovarian cancers, for which PARP inhibitors (PARPi) are becoming a preferred treatment option.However, a considerable proportion of these carcinomas acquire resistance or harbour de novo resistance, posing a significant challenge to

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Advanced Integrated Driver Information Systems

Future driver information systems will consist of a plurality of information components containing the classic instrumentation like Accessories instrument cluster, radio and trip computers, but also new components like car telephones, navigation systems and even TV.This development leads firstly to a new kind of instrument cluster design and second

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Localised estimates and spatial mapping of poverty incidence in the state of Bihar in India-An application of small area estimation techniques.

Poverty affects many people, but the ramifications and impacts affect all aspects of society.Information about the incidence of poverty is therefore an important parameter of the population for policy analysis and decision making.In order to provide specific, targeted solutions when addressing poverty disadvantage small area statistics are needed.S

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A review of global and regional frameworks for the integration of an unmanned aircraft system in air traffic management

Unmanned aircraft system (UAS) applications have increased exponentially in recent years owing to their low cost, improved performance, and the use of advanced technology in this relatively new and rapidly evolving industry.Despite the advanced technologies used in UASs, the integration of UASs into the air traffic management regulatory framework i

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